The "Drug Design" course construction of the School of Pharmacy of Fudan University won the second prize of National Teaching Achievement, the first prize of Shanghai Teaching Achievement, the key course of Shanghai Education Commission (2011) and the Shanghai Excellent Course (2012).
The courses are based on the disciplines of life sciences, chemistry and bioinformatics, theoretical chemistry, organic chemistry, and medicinal chemistry related to drug discovery, and are set up 25 theoretical and 8 experimental knowledge points around the theoretical system of drug design, research strategies and methods, experimental principles and operations, and problem discussions, including: introduction, drug targets and their theories, structure-based drug design, lead compound property design optimization, computer-aided drug design experiments; Experimental courses include sequence alignment, protein structure demonstration, the construction and optimization of the three-dimensional structure of small molecules, the construction of small molecule pharmacophore models, and molecular docking, which will greatly help students apply pharmaceutical design to their own scientific research.
Drug Design is an emerging subject that constantly explores the unknown, and it is also a professional course suitable for cultivating innovative thinking and independence of students majoring in biomedicine. Undergraduate or graduate students in pharmacy, chemistry, biology, medicine and other related fields are suitable for this course.
Chapter 1 Introduction
Overview of Drug Design (Part 1)
Overview of Drug Design (Part 2)
Basic principles of drug design
Lead compound discovery pathway
Chapter 2 Drug Targets and Theories
Target concept
Hypothesis of Drug Target
Classification of Drug Targets
Relevance of Drug Targets
Classical vs. Modern Drug Discovery
Chapter 3 Drug Design Based on Structure (Part 1)
SBDD overview
Basic theory, technology and method
Theoretical calculation method of molecular three-dimensional structure
Molecular modeling technology
Chapter Three Drug Design Based on Structure (Part 2)
Direct Drug Design I
Direct Drug Design II
Indirect drug design Ⅰ
Indirect Drug Design II
Chapter 4 Lead Compound Property Design Optimization (Part 1)
Basic properties of drugs
Structure-kinetic relationship and pharmacokinetic group
The relationship between macroscopic properties of drugs and pharmacokinetic properties
Drug-like and empirical rules
Chapter 4 Lead Compound Property Design Optimization (Part 2)
The concept of druggability and its evaluation methods in vivo and in vitro
CYP450 inhibition and drug toxicity (part 1)
CYP450 inhibition and drug toxicity (part 2)
How to reduce hERG toxicity and drug optimization strategies
Chapter 5 Computer Aided Drug Design Experiment (Part 1)
Sequence Alignment
Protein structure display
Construction and optimization of three-dimensional structures of small molecules
Chapter 5 Computer Aided Drug Design Experiment (Part 2)
Pharmacophore Construction (Part 1)
Pharmacophore Construction (Part 2)
Molecular docking (Part1)
Molecular docking (Part2)
Basic knowledge of chemistry and pharmacy
《药物设计学》第3版（叶德泳、付伟编写，高等教育出版社，2015） 《计算机辅助药物设计导论》第2版（付伟、叶德泳编写，化学工业出版社，2017） 《计算机辅助药物设计》（陈凯先、蒋华良编写，上海科学技术出版社，2000） 《Comprehensive Medicinal Chemistry II》（John B. Taylor 、David J. Triggle编写，Elsevier，2007） 《药物设计策略》（郭宗儒编写，科学出版社，2012）
Professor
由高教社联手网易推出，让每一个有提升愿望的用户能够学到中国知名高校的课程，并获得认证。
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