spContent=以“思辨”、“融汇”、“创新”为指导思想，帮助你掌握遗传学基本概念，解读遗传学经典实验，探索遗传学前沿进展。
以“思辨”、“融汇”、“创新”为指导思想，帮助你掌握遗传学基本概念，解读遗传学经典实验，探索遗传学前沿进展。
—— 课程团队
课程概述
遗传学探究生物遗传和变异规律，是一门古老而又年轻的学科。对遗传规律的应用可以追溯至史前人类对农作物和家畜的驯化。近年来，随着二代测序和基因编辑等新技术的突破，遗传学的前沿发展日新月异，正不断深入地刻画着我们对于基因型和表型关系的认知。现代遗传学的研究，在解析基本生物学现象的分子基础，揭示疾病的分子机制、动物和植物的分子设计育种等方面发挥重大作用。本课程为你解析遗传学的基本概念和关键知识点，讲述关键科学发现的背景和意义，融汇贯通基本知识框架和前沿进展，逐步建立以科学问题为导向的科研思维。
授课目标
《遗传学》是所有生命科学相关专业的基础课，与分子生物学，发育生物学，进化生物学等生物学的分支存在广泛的交叉融合。本课程的学习将帮助你完成以下三个目标：
1. 掌握经典遗传学，分子遗传学和群体遗传学的基本原理，知识框架和相关专业英语词汇。
2. 具备应用相关知识解析遗传学现象的能力，掌握遗传学研究的基本策略和方法，提升文献阅读能力。
3. 对遗传学学科的历史、现状和前沿方向以及遗传学与生物学其他分支的交叉和融合有较为完整和深入的认识。
课程大纲
Introduction to genetics
1.1 The Importance of Genetics
1.1.1 Why study genetics?
1.1.2 Model Organisms
1.2 The History of Genetics
1.3 Fundamental Concepts in Genetics
Chromosomes and Cellular Reproduction
2.1 Prokaryotic and Eukaryotic Cells
2.2 Cell Reproduction
2.3 Sexual Reproduction and Meiosis
Basic Principles of Heredity
3.1 Basic Principles of Heredity
3.1.1 Mendel's Success
3.1.2 Principle of Segregation
3.1.3 Probability as a Tool in Genetics
3.1.4 Principle of Independent Assortment
3.2 The Goodness-of-Fit Chi-Square Test
Sex Determination and Sex-linked Characteristics
4.1 Sex Determination Mechanisms
4.1.1 Sex Determination
4.1.2 Examples of Genotypic and Environmental Sex Determination
4.1.3 Complexity of Sex-Determination
4.2 Inheritance of Sex-linked Characteristics
4.2.1 X-linked white eye in Drosophila
4.2.2 Non-disjunction and the Chromosome Theory of Inheritance
4.2.3 Examples of Sex-linked Characteristics
4.2.4 Random X-inactivation
Extensions and Modifications of Basic Principles
5.1 Additional Factors at a Single Locus
5.1.1 Types of Dominance
5.1.2 Penetrance and Expressivity, Lethal Alleles, and Multiple Alleles
5.2 Gene Interaction
5.2.1 Gene Interaction with Epistasis
5.2.2 Examples of Epistasis
5.2.3 Gene Interaction that Produces Novel Phenotypes
5.2.4 Complementation Test
5.3 Sex Influences the Inheritance and Expression of Genes
5.3.1 Sex-influenced and Sex-Limited Characteristics
5.3.2 Cytoplasmic Inheritance
5.3.3 Maternal Effect
5.3.4 Genomic Imprinting
5.4 Anticipation
5.5 Environmental Effects
Linkage, Recombination, and Eukaryotic Gene Mapping
6.1 Linkage, Crossing Over and Recombination
6.1.1 Crossover and Recombination
6.1.2 Predicting the Outcomes of Crosses with Linked Genes
6.1.3 Evidence of the Physical Basis of Recombination
6.1.4 Testing for Independent Assortment
6.2 Gene Mapping with Recombination Frequencies
6.2.1 Recombination frequency and distances between genes
6.2.2 Constructing a genetic map with two-point testcross
6.2.3 Constructing a genetic map with three-point testcross
6.2.4 Locating genes with molecular markers
6.3 Physical Mapping Methods
Chromosome Variation
7.1 Types Chromosome Mutations
7.2 Chromosome Rearrangements
7.2.1 Duplications and Deletions
7.2.2 Inversions
7.2.3 Translocations
7.3 Aneuploidy
7.4 Polyploidy
Bacterial and Viral Genetic Systems
8.1 Genetic Analysis of Bacteria
8.2 Gene Transfer in Bacteria
8.2.1 Conjugation
8.2.2 Transformation
8.3 Virus Genetic Analysis
8.3.1 Transduction
8.3.2 Gene Mapping in Phages
8.3.3 RNA Virus
Molecular Genetics and Biotechnology
9.1 CRISPR-Cas9 Gene Editing
9.2 Next Generation Sequencing
Epigenetics
10.1 Epigenetics: Fundamentals
10.2 Molecular Processes That Lead to Epigenetic Changes
10.2.1 DNA Methylation
10.2.2 Histone Modifications
10.2.3 Non-coding RNAs
10.3 Diverse Roles of Epigenetic Regulation
10.3.1 Epigenetic regulation underlines temperature-dependent sex determination
10.3.2 Epigenetic regulation of flowering
Developmental Genetics and Immunogenetics
11.1 Genetic Control of Development
11.1.1 Cell Determination and Pattern Formation
11.1.2 Egg Polarity Genes
11.1.3 Segmentation Genes and Homeotic Genes
11.1.4 Genetic Control of Flower Development
11.2 The Study of Development Reveals Patterns and Processes of Evolution
11.2.1 Deep Homology
11.2.2 Evolutionary Changes in Gene Expression
11.3 Genetic Rearrangement and the Development of Immunity
Cancer Genetics
12.1 Cancer as a Genetic Disease
12.2 Oncogenes and Tumor-Suppressor Genes
12.3 Chromosome Mutations and Cancer
12.4 Viruses are associated with some cancer
Quantitative Genetics
13.1 Quantitative Characteristics
13.1.1 Types of Quantitative Characteristics
13.1.2 Polygenic Inheritance
13.2 Statistical Methods for Analyzing Quantitative Characteristics
13.3 Heritability
13.4 Selection Response
Population Genetics
14.1 The Gene Pool of a Population
14.2 The Hardy-Weinberg Law
14.2.1 Hardy–Weinberg Equilibrium
14.2.2 Testing for Hardy-Weinberg Proportions
14.2.3 Non-random Mating
14.2.4 Mutation and Migration
14.2.5 Genetic Drift and Natural Selection
Evolutionary Genetics
15.1 Biological Evolution
15.2 Reproductive Isolation and Speciation
15.3 Phylogeny
15.4 Evolution at the Molecular Level
展开全部
预备知识
参考资料
Genetics: A Conceptual Approach, 7th Edition by Benjamin A. Pierce W. H. Freeman
遗传学（第3版）刘祖洞，乔守怡，吴燕华，赵寿元 著， 高等教育出版社
遗传学（第3版）戴灼华，王亚馥 著， 高等教育出版社
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