Pharmacology is a subject that studies the interactions between the drug and the body (including pathogens). Not only the effects and mechanisms of the drug, but also the dynamic changes influenced by the body are all investigated in the course. Based on the basic medical sciences including physiology, biochemistry, pathology, pathophysiology, microbiology, immunology, molecular biology, pharmacology provides the basic theory and scientific thinking method for prevention and treatment of diseases, rational drug usage.
Pharmacology is a bridge subject among the pharmacy, basic medicine and clinical medicine. The aims is to enable students to master the pharmacological effect, mechanism of action, clinical applications, adverse reactions and the interactions between drugs through theoretical pharmacology and experimental training, and finally to solve problems independently and to cultivate the students' scientific thinking patterns. The task of pharmacology is to guide rational usage of drug, to provide a theoretical basis for disease prevention and treatment, to set up the necessary pharmacological foundation for s pharmaceutical research and new drug development and research.
Through the study of "Pharmacology" on MOOC, you can grasp the basic principles and characteristics of drug action, understand how to use drugs correctly to prevent and treat diseases, and also provide guidance for clinical rational drug uses.
General principle of pharmacology (1)
1.1 Introduction (what is pharmacology?)
1.5 Important parameters of pharmacokinetics (How can we measure you, Mr. Drug?)
1.4 Drug disposition (A magic trip for Mr. Drug)
1.3 Factors affecting passive transport (Which one can pass, ionized drug or unionized drug?)
1.2 Transmembrane transport of drug molecules (Several ways to pass through the membrane)
Quiz for Week 1
General principle of pharmacology (2)/Drugs affecting autonomic nerve system (1)
1.8 Drugs and receptors (Routines in the drug world)
2.1 Classification of autonomic nervous system (Ubiquitous control network)
2.2 Transmitters of autonomic nervous system (The "diligent" messagers)
1.6 Adverse effects (The Kung Fu of Mr. Drug)
2.5 The basic mode of action and classification of ANS (Super family)
2.3 Receptors of autonomic nervous system (Various "locks")
2.4 Physiological function of autonomic nervous system (The magic power of ANS)
1.7 Dose-response relationship (Pay a return )
Quiz for Week 2
Drugs affecting autonomic nerve system (2)
2.9 Atropine (A generalist from Atropa belladonna)
2.6 Muscarinic receptor agonist: Pilocarpine (The killer of glaucoma)
2.8 Organophosphorus pesticide (Insects, you have nowhere to escape)
2.10 Other M receptor blockers ("wandering" Gemini)
2.7 Neostigmine and physostigmine (Twins with different surnames)
2.12 Nn cholinergic receptor blocker: Non-depolarizing muscle relaxant (A magic herb from South America)
2.11 Nm cholinergic receptor blocker: Depolarizing muscle relaxant (Let’s relax!)
Quiz for Week 3
Drugs affecting autonomic nerve system (3)
2.13 Adrenaline (Full of beans)
2.15 Noradrenaline (Super king)
2.17 α-adrenoceptor blocker (an expert at relaxing blood vessels)
2.14 Dopamine and ephedrine (The ancient medicines)
2.18 β-adrenergic receptor blocker (Romeo, for heart disease)
2.16 Isoproterenol (Feelings of flipped flipped)
Quiz for Week 4
Drugs affecting central nerve system
3.5 Morphine and the other opioid receptor agonists (remedy or addiction?)
3.1 Benzodiazepines: sedative and hypnotic (No longer worried about sleeplessness)
3.6 Antipyretic, analgesic and anti-inflammatory drugs (fever! Pain! Inflammation! )
3.3 Anti-Parkinson drugs (Imbalance between DA and Ach)
3.2 Antiepileptic drugs (Excessive discharge)
3.4 Antipsychotic drugs (Gospel for the insane)
Quiz for Week 5
Drugs affecting cardiovascular system (1)
4.2 Characteristics of different calcium channel blockers (The same or the different)
4.6 Renin-angiotensin system inhibitor: ACEIs (Enzyme inhibitor and blood pressure)
4.5 Antihypertensive drugs: Adrenergic receptor blockers (How do β-blockers reduce blood pressure?)
4.8 Antihypertensive drugs with CNS action (Starting from "brain")
4.4 Overview of hypertension and classification of antihypertensive drugs (Let’s talk about blood pressure)
4.9 Vasodilator - potassium channel opener (New idea of vasodilator)
4.11 Anti-angina effects of nitroglycerin (The Savior of angina)
4.10 Pathophysiological basis of angina and classification of anti-angina drugs (Why "heartache"?)
4.7 Renin-angiotensin system inhibitor: ARBs (Blocking receptors is also effective)
4.3 The pharmacological effects of calcium channel blockers (Effects on heart and blood vessels)
4.12 β receptor blocker combined with nitrates for angina pectoris (Combination is strength)
4.1 Classification of voltage-dependent calcium channel and calcium channel blockers (Family of CCBs)
Quiz for Week 6
Drugs affecting cardiovascular system (2)
4.19 Cardiac glycosides: Positive inotropic action and its mechanism (Why is it so powerful? )
4.16 Classification of antiarrhythmic drugs and class I antiarrhythmic drugs (sodium and rhythm of the heart)
4.20 Cardioglycosides: Manifestations of drug toxicity and the measures for prevention and treatment (Dosage, be careful!)
4.18 Pathophysiological changes and therapeutic drug classification of therapy congestive heart failure (What to do if the heart is "broken"?)
4.21 Clinical uses of cardiac glycosides (Heart failure therapy and antiarrhythmia)
4.17 Class II, III and IV antiarrhythmic drugs (Choosing antiarrhythmic drugs according to symptoms)
4.13 Basis of cardiac electrophysiology (Consider the past, and you shall know the future)
4.14 Main factors affecting action potential (Seek the origin)
4.15 Mechanism of arrhythmia: reentry (So that’s it)
Quiz for Week 7
Drugs affecting visceral system
5.4 Antiasthmatic drugs (Conquer the breathlessness)
5.5 Drugs for inhibiting gastric acid (Control gastric acid)
5.1 Physiological basis of diuretics ( Renal tubules and glomeruli)
5.2 Commonly used diuretics (Three brothers in diuretics family)
5.3 Anticoagulants (Bleeding, what's the matter?)
5.6 gastric mucosal protection and anti-H pylori drugs (Full range security)
Quiz for Week 8
Drugs affecting endocrine system
6.4 Insulin and oral hypoglycemic drugs ("life saving straw of diabetic")
6.3 Thyroid hormone and antithyroid drugs (Who can defeat the hyperthyroidism)
6.1 Function of glucocorticoids (A master key )
6.2 Clinical application and adverse reactions of glucocorticoids (Merits and demerits)
Quiz for Week 9
Chemotherapeutic Drugs
7.4 Synthetic antibiotics: Quinolones + Sulfonamides (We are not natural ones! )
7.2 Macrolide antibiotics (Effects of erythromycin)
7.3 Aminoglycoside antibiotics (Side effects of deafness)
7.1 β - lactam antibiotics (Be careful of allergic reactions!)
Quiz for Week 10
Students should have the basis of medical knowledge on physiology, cell biology, molecular biology, microbiology, immunology, pathophysiology, pathology, etc.
Basic Reference Book:
1. Lippincott Illustrated Reviews: Pharmacology (6th edition), LWW
Further Reference Books:
2. Basic and Clinical Pharmacology (12th edition), McGraw-Hill Education,LANGE
3. Principles of pharmacology: The pathophysiologic basis of drug therapy, (3th edition), LWW
4. Goodman & Gilman's, The Pharmacological Basis of Therapeutics (11th edition), McGraw-Hill
1. Learners should firstly log in the website: https://www.icourses.cn, and then register an account of icourses;
2. Please Log in with the applied icourses account, enter the home page of icourses website, then click "MOOC of China University" and search "Pharmacology" to find the corresponding course icon. When we start the classes, you can use the learning page to learn "Pharmacology".
3. Note: During the study of our course, you must use the same learning account to log in. Please don’t change the learning account, or your score will be affected.